During the past few decades substantial progress has been made in the care of patients with critical illness. However, several key developments are necessary to further improve outcomes: (1) preclinical studies need realistic models of acute and chronic critical human illnesses; (2) retrospective and prospective observational studies should leverage rapidly evolving digital technology with big-data capability for analysis and patient monitoring; and (3) RCTs should consider novel designs and incorporate appropriate biomarkers to facilitate a personalized approach to evidence development and care delivery. These suggestions are expected to improve acute outcomes and long-term quality of life for critically ill patients and represent a starting point for setting new directions in critical care medicine and research.
Amazing! Life-saving treatments in the critical care arena can have a life-long impact on the patient; imagine a world where phenotypes, biomarkers and genetics help dictate the type of treatment patients receive to ensure a more positive outcome for both the short and long term quality of life for the patient.